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Sample Preparation in NGS And Why Good Results Matter

NGS Sample Preparation Market

Removing RNA or DNA particles from tissues is vital for the making of libraries. Thus, RNA or DNA removal quality is important for attaining better results in NGS. Low-quality DNA or RNA removals can be polluted with proteins or carbon-based compounds like polyphenols. And it might make library preparation difficult in numerous forms.

For example, for those libraries where polymerase chain reaction is utilized, extraction uncleanness makes intensification complex and might impact the outcomes. In other cases, impurities might decrease the effectiveness of the sequencing of target molecules.

NGS sample preparation market is witnessing growth and is projected to reach USD 5,501.2 million by 2030.

Increasing Acceptance of Next-Generation Sequencing for Hereditary Disorders

For the analysis of genetic syndromes, NGS is extensively utilized. The surging usage of next-generation sequencing in diagnostic labs has enhanced the accuracy and reliability of genetic diagnosis. Prenatal analysis and prophetic genetic testing are both using progressive genetic diagnostic methods.

The constancy and efficiency of diagnostic screening tests are becoming more important as the count of individuals going through many genetic illnesses increases. To efficiently monitor a genetic illness, quicker results with negligible faults are needed. The dependability and throughput of sample preparation for genomic sequencing will be improved with the automated NGS sample preparation.

Infectious Illnesses Are the Fastest-Rising Therapeutic Area

The next-generation sequencing aids in identifying communicable illnesses, mainly illnesses resulting from mixed contaminations, which is a severe problem. To decrease the load of infectious illnesses, the submission of several samples to labs is needed in a huge number.

Also, enhancements in next-generation sequencing tech have unlocked the prospect of emerging a complete strategy for classifying communicable pathogens.

NGS has been utilized to monitor and identify novel diseases and sicknesses that escape standard testing. The tech can continuously advance and spot each pathogen, which might exist in a sample, allowing worldwide and unbiased pathogen discovery. This has outcome in a hike in the use of NGS tools and consumables in general, involving specimen preparation.

Growing Demand for Genomics Research: There is a rising demand for genomics research, mainly in areas like modified medication, rare disease diagnostics, and cancer research. This demand is propelling the acceptance of NGS tech, such as NGS Sample Preparation, which is vital for generating high-quality sequencing information.

Expansion Into Clinical Applications: NGS tech is progressively being accepted for scientific applications, like prenatal testing, cancer diagnostics, and infectious disease testing. This gives an opportunity for businesses in the NGS sample preparation industry to advance products that are custom-made to the requirements of clinical labs and fulfill regulatory needs.

Asia-Pacific: APAC is the fastest-rising industry for NGS sample preparation, propelled by growing government steps to aid genomics research and modified medication, rising requirements for NGS tech in medical applications, and the existence of a huge patient populace. India, China, and Japan are the key industries in this region, with other Asian nations also contributing to the development of the industry.

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Why Will Proton Therapy Rule the Particle Therapy Industry?

Particle Therapy Industry

The global particle therapy market is experiencing growth and is projected to reach USD 1,634.4 million by 2030. This development can be attributed to the high acceptance of particle treatment for cancer treatment armed with the rise in the count of particle therapy centers throughout the globe.

In recent years, proton therapy dominated the industry with a revenue share of above 90%, and the category is also estimated to experience a higher CAGR, of around 8.5%, in the projection period. This development can be credited to the high acceptance of this treatment for treating numerous cancers, like brain tumors, pediatric cancer, and breast cancer.

According to a government agency, above 2 million females were identified with breast cancer in 2020 throughout the globe, making it the most prevalent cancer. Products, like synchrotrons, cyclotrons, and synchrocyclotrons, hold over 80% of the industry share, credited to the increasing acceptance of cyclotrons in numerous hospitals armed with numerous benefits provided by them like low prices. Furthermore, the increasing shift toward nuclear scans for analysis, and the accessibility of technically progressive diagnostic devices also propel the industry development in this category.

During the projection period, the single-room systems category is projected to experience a higher CAGR, of approximately 9%, because of the low price per treatment and lower development price of a single-room facility. For example, according to a government source, the price of a single-room facility is approximately USD 30 million, which is relatively very high in the case of a multi-room capacity that can price approximately USD 100 million.

In recent years, pediatric cancer accounted for over 25% of the particle therapy market share, and the category is estimated to witness the fastest development, growing at a CAGR of approximately 9.0%, in the projection period, credited to its high occurrence throughout the world. Particle treatment is typically utilized in the treatment of pediatric patients because of the high mitosis rate in kids, which needs treatment that straight targets the tumor with very less long-term side effects. It offers high accuracy and radiation control with nearly no exposure to normal body cells.

In recent years, the European particle therapy industry generated the highest revenue share. Moreover, the regional industry is projected to witness the highest CAGR, of approximately 9%, in the projection period, because of the increasing count of particle therapy amenities offering clinical processes in the region. For example, above 50% of the particle therapy centers exist in Europe.

This is due to the supportive government guidelines and the existence of technologically progressive solutions for illness diagnosis. Furthermore, the existence of a huge count of distribution platforms also boosts the industry development in the region.

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High Prominence of Downstream Processing Due to Reduced Operational Cost

Downstream Processing Industry

Downstream processing can be defined as the series of operations for biological materials such as plant tissues, tissue culture fluid, and cells to derive them from a homogenous product. The rising expenditure on research & development in the biopharmaceutical sector, along with the growing prevalence of contract manufacturing organizations, and the expansion of the biotechnology sector leads to increasing adoption of downstream processing.

In 2021, the downstream processing industry generates $21.1 billion, and it is expected to capture $51.0 billion in 2030, advancing at a rate of 10.3% from 2021 to 2030. The product is initially enclosed in the biological matrix with a massive number of varying non-target molecules. Moreover, downstream processing involves multiple processes that incrementally boost the target’s purity by exploiting its chemical and physical properties, making it distinct from contaminants.

Downstream processing involves harvesting and clarification steps for separating bulk contaminants from it such as carbohydrates, particulates, and oils, after polishing and capturing, and refining the feed stream till only the target product is left.

Moreover, downstream processing for energy effectiveness constitutes multistage unit operations after upstream processes that help in the enhancement of the final product’s quality in terms of both purity and concentration.

The major objective of downstream processing, along with maximizing the recovery rate of the product, is to minimize the production cost. The cost-effective production largely relies on the product’s nature, selection of feedstocks, as well as fermentation process, along with immobilized cells fermentation, free cells, and catalyst types.

In addition, downstream processing is an integral part of the entire production process, and numerous factors affect it. Along with bioprocess, raw materials usage, and specifications of the final product relies on DSP. It includes formulation, or direct in situ use, such as polymerization. Around 50% to 90% of the total production cost is consumed by the DSP.

The selection of the DSP relies on the type of microorganism, fermentation process, product substrate, along with target application. Varying combinations of steps with varying unit operations are utilized in most cases. As it is mentioned, numerous by-products could be generated from succinic acid fermentation, possessing similar structures and properties, such as lactic acid, and malic acid, along with their selective separation that largely affects DSP costs.

Downstream processing constitutes all unit operations after fermentation to enhance the final product, ethanol’s purity. Usually, combinations of molecular sieving and distillation are used for ethanol purification.

Ethanol contains only 5% of moisture, that is dehydrated while using azeotropic distillation. The water presence improves ethanol’s molecular polarity and keeps it separate when mixed with gasoline. Entrainer, a third chemical is then added, in azeotropic distillation. In large-scale ethanol purification, molecular sieving methods are implemented, as azeotropic distillation is expensive.

In the pharmaceutical sector, downstream processing holds a greater prominence in significantly reducing the whole manufacturing process cost. Microfiltration, ultrafiltration, nanofiltration, and reverse osmosis are largely utilized for pharmaceuticals’ downstream processing due to ease of operations.

Therefore, downstream processing is essential and holds a greater prominence in the biopharmaceutical, and biotechnology sectors in significantly reducing the operational cost.

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Clinical Trials Outsourcing Industry to Observe Fastest Growth In Asia-Pacific

Clinical Trials Outsourcing Market

The clinical trials outsourcing market will touch USD 75,573.4 million, advancing at a 7.2% compound annual growth rate, by 2030.

The advancement in this industry can be ascribed to the surging requirement to enhance efficiency and lessen research and development expenses. Furthermore, the growing count of non-communicable and communicable diseases, mounting research & development activities to manufacture new medicines, and the rising pharmaceutical & biopharmaceutical sectors, are also boosting the progression of this industry.

Additionally, governments in some nations are increasing their focus on the healthcare sector, because of the mounting incidence of people with chronic illnesses, for instance, cardiovascular diseases, lung cancer, and diabetes. Moreover, non-government and government organizations are also rising their focus on the efficacy and safety of the drug.

The phase-3 category, based on phase, held the largest share of the industry, of over 36%, in the past few years. This is because of the large number of clinical trials present in the stage of phase-3 and the high failure possibility in clearing this stage, which encourage pharmaceutical businesses to partner with outsourcing partners.

The small & mid-sized companies category, based on end user, is expected to dominate the clinical trials outsourcing market in the years to come. This is because of the increasing number of contract research organizations, mainly in Asian nations such as China, Japan, and India, which provide solutions for end-to-end clinical trials, enabling resource flexibility, resource sharing, operational capabilities expansion, and cost-efficiency.

In the past few years, the cancer category, based on application, accounted for the largest share in the industry. This is primarily because of the surging incidence of cancer, which needs precise medications to prevent, reduce pain, and cure cancer.

The nervous system disorder category will observe the highest growth rate in the years to come. This is because of the surging incidence of nervous system disorders, such as migraine, tension-type headaches, traumatic brain injury, and dementias. Furthermore, the unavailability of important medications is boosting the requirement for drug development.

The North American industry accounted for the largest share in recent years. This is because of the existence of enhanced healthcare infrastructure, an increasing number of innovative drug research studies, high healthcare spending, the existence of major players, and high funding for clinical trials in the continent.

APAC will observe the fastest growth in the industry, with more than 7.5% CAGR, in the years to come. This is primarily because of the rising activities of drug research, the increasing incidence of diseases, and the advancing healthcare infrastructure in the continent.

It is because of the increasing production of new medications and the growing number of contract research organizations, the clinical trials outsourcing industry will continue to advance in the years to come.

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Biologics CDMO Secondary Packaging Industry Will Grow Fastest in Asia-Pacific

Biologics CDMO Secondary Packaging

The biologics CDMO secondary packaging market will touch USD 3,622.6 million by 2030, powering at a rate of 8.7% by the end of this decade. This growth is credited to the snowballing drug production, the increasing pharma industry, and the growing prevalence of numerous diseases, such as chronic ailments, infectious ailments, and genetic diseases.

Boxes were the largest category in the industry, with about USD 1 billion revenue, in 2021, and they will continue dominations in the years as well.

Boxes are designed explicitly for the transport of biological products, such as frozen and controlled ambient biologics. They also provide the perfect balance between temperature control and payloads.

North America had the largest revenue share, more than 40%, in the biologics CDMO secondary packaging market. This is because of the increasing outsourcing of drug research and development and production activities by major biopharma players.

Numerous companies wish to team up with competent packing providers providing non-conventional packing solutions and have the vital capabilities to formulate exclusive packing designs in a time and cost-effective manner.

Instead, the APAC will have the fastest growth in the years to come. This growth has a lot to do with the increasing prevalence of chronic ailments, the growing emphasis of businesses on contract manufacturing, and key players are keenly interested in facility developments in the Asia Pacific region.

Furthermore, the growth of the European region will be moderate in nature in the years to come. This can be mainly as a result of the increasing requirement for biologic products, for instance vaccines, driving the research and development spending of the pharma companies.

Due to the increased production of drugs all over the world, the demand for biologics CDMO secondary packaging is on the rise, and this trend will continue in the years to come as well.

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Hematology Testing – Industry Growth and Future Analysis

Hematology Testing Industry

The hematology testing market generated a value of USD 3,987.4 million in 2022, and it will touch USD 6,335.9 million, growing at a 6.0% compound annual growth rate, by 2030.

The growth of the industry is mainly because of the increasing incidence of blood-related illnesses and the growing usage of high throughput hematology analyzers as well as advancements in technology.

In 2022, the consumables category, based on product, contributed a larger revenue share, of approximately 70%, and it will also observe a higher growth rate, of approximately 7%, in the years to come. The growth in this category is primarily because of the widespread adoption of numerous reagents and test kits to perform hematology testing.

In 2022, the reagents category, among the consumables, accounted for the largest share of approximately 60%, and it will exhibit the highest growth rate of approximately 5% in the years to come. This is because of the mounting number of laboratory tests number, as a result of the growing prevalence of infectious and chronic illnesses.

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In 2022, the global hematology diagnostics industry is led by North America, with approximately USD 2 billion, owing to the advantageous patient demographic, favorable policies of reimbursement, and increasing incidence of numerous types of blood diseases in the region.

APAC will observe the highest growth rate in the industry, of approximately 8%, in the years to come, owing to the mounting number of blood camps, growing government investments, rising consciousness about blood donation, and increasing blood disorders incidence in the region.

Moreover, India and China together hold over 50% share of the APAC industry, owing to the high acceptance of flow cytometry in these nations.

Hence, with the increasing incidence of blood-related illnesses and mounting acceptance of high-throughput hematology analyzers, the hematology testing industry will continue to advance in the years to come.

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Here are 7 Superfoods for Optimal Skin Health

When it comes to achieving glowing and radiant skin, people often rely on expensive skincare products and beauty treatments. However, what many people tend to overlook is the significant impact of their diet on skin health.

The saying “you are what you eat” holds for our skin as well. Consuming a balanced diet that includes skin health foods can work wonders for maintaining a clear, youthful, and vibrant complexion.

Let’s explore seven superfoods that can contribute to optimal skin health, providing essential nutrients and promoting a natural, healthy glow.

Avocado

Known for its high content of healthy fats, avocados are a powerhouse of skin-friendly nutrients. They are packed with monounsaturated fats that help keep the skin moisturized and flexible, reducing the appearance of fine lines and wrinkles.

Additionally, avocados contain vitamins E and C, which act as potent antioxidants, protecting the skin from oxidative damage caused by free radicals.

Sweet Potatoes

Rich in beta-carotene, sweet potatoes are a skin-friendly food that can give your skin a healthy glow. Beta-carotene is converted to vitamin A in the body, which is essential for skin cell turnover and repair. Regular consumption of sweet potatoes can help prevent dry, flaky skin and promote a smoother texture.

Green Tea

Green tea is not only a soothing beverage but also a potent skin health booster. It contains catechins, which have anti-inflammatory and antioxidant properties that can help reduce redness and inflammation. Additionally, green tea can help protect the skin from damage caused by sun exposure and pollution.

Greek Yogurt

Greek yogurt is a great source of probiotics, which play a vital role in promoting a healthy gut. A balanced gut microbiome can positively impact skin health by reducing inflammation and preventing skin conditions like acne and eczema.

Dark Chocolate

Indulging in moderate amounts of dark chocolate (with high cocoa content) can be beneficial for your skin. Dark chocolate is rich in flavonoids, which can enhance blood flow to the skin, improve hydration, and protect against sun damage. Additionally, the antioxidants in dark chocolate can help combat free radicals, promoting a more youthful appearance.

Nuts and Seeds

Almonds, walnuts, chia seeds, and flaxseeds are excellent sources of healthy fats, antioxidants, and vitamins that benefit the skin. Vitamin E in nuts and seeds helps protect the skin from UV damage, while their omega-3 fatty acids maintain skin elasticity and hydration.

Salmon

Salmon is an excellent source of omega-3 fatty acids, which are essential for maintaining skin health. These healthy fats help to keep the skin hydrated and reduce inflammation, promoting a clear and radiant complexion. Omega-3s also support the skin’s natural barrier, which protects against environmental pollutants and irritants.

Additionally, the consumption of fatty fish and walnuts is very high due to the high presence of fatty acids, these acids have numerous benefits, which is why they are now being increasingly utilized in the skincare and beauty industry.

Moreover, these skin health foods are consumed by both adults and elderly people, however, because of the larger population of adults than that of elderly people around the world, these foods are mostly consumed by adults.

Incorporating these skin-boosting foods into your diet, along with a good skincare routine, proper hydration, and sufficient sleep, can contribute to achieving radiant, beautiful skin that glows from within.

Moreover, with the surging R&D spending by a large number of local and foreign businesses producing functional foods and the rising knowledge of the health benefits of functional foods across Asian countries, the need for skin health foods is increasing, and it will reach a value of USD 3,438.9 million by the end of this decade.

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Metagenomic Sequencing Industry Share, Growth and Future Analysis

Metagenomic Sequencing Market

The metagenomic sequencing market was USD 1,938 million in 2022, and it will reach USD 6,899 million, advancing at a 17.20% compound annual growth rate, by 2030.

The growth in the industry is because of the decreasing cost of this technique. Furthermore, the implementation of this technique is increasing in agricultural biotechnology, where it allows the analysis of the whole genome in an environmental sample without the need for culturing.

In 2022, the drug discovery category, based on application, held the largest share, of over 26%, and it will remain the largest in the years to come. This is because of the rising activities of research in the biotechnical and pharmaceutical industries for novel drug discovery, regularly as part of partnerships between academic institutes and industry players.

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Whereas, the clinical diagnostics category will observe the highest growth rate in the metagenomic sequencing market, in the years to come. This is primarily because of the increasing prevalence of infectious illnesses and the production of tools and software for genomic research.

The shotgun metagenomic sequencing category, based on technology, held the largest share, and it will remain the largest in the years to come. This is because of the surging genomic-based research activities led by academic and research institutes and the benefits provided by this technique as compared to other techniques.

In 2022, the sequencing category, based on workflow, accounted for the largest share of the metagenomic sequencing industry, and it will remain the largest in the years to come.

Sequencing methods are regularly utilized by research scientists and healthcare institutions for genetic studies, which is an important component of genetic testing. The price of sequence modeling has dropped by approximately 28% annually because of technological advancements, which would boost its utilization.

In 2022, North America accounted for the largest share, of over 42%, and it will observe a strong growth rate in the years to come. This is because of the higher risk of illnesses, extensive R&D activities in the pharmaceutical and biotechnology sectors, ad full-bodied support for the setup of new R&D facilities, and the presence of reputable healthcare businesses in the continent.

Whereas, APAC will observe the fastest growth rate in the years to come. This is because of the surging investment by domestic and international businesses, government support for research in advanced healthcare areas, development of the healthcare infrastructure, and a large pool of patients with infectious and chronic illnesses.

With the increasing incidence of genetic and infectious illnesses, as well as government investments in healthcare research and development, the metagenomic sequencing industry will continue to grow in the years to come.

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Plasma Fractionation Industry Development and Forecast Report 2030

Plasma Fractionation

The plasma fractionation market will observe a rate of 7.4% by the end of this decade, to reach USD 50,638 million by 2030.

The industry growth has a lot to do with the fast increase in the elderly population, susceptible to various rare disorders creating the requirement for plasma derivatives for treatment.

Furthermore, the industry is expanding because of the growing use of immunoglobulins in numerous therapeutic areas, increasing incidence of breathing problems, and mounting network of facilities of plasma collection.

The surge in the geriatric population all over the world is also a key factor accountable for the growing incidence of numerous uncommon disorders that require the usage of blood derivatives. With the count of people aged 65 and above will cross 1.5 billion by 2050, the use of the plasma fractionation method for deriving Ig and other therapeutic agents from the blood will increase.

On the basis of the product type, the immunoglobulins category will grow significantly at a rate of 7.9%, in the years to come. This is because of the wider commercial obtainability of plasma-derived immunoglobulins as opposed to other products and their growing use, particularly for treating patients with chronic inflammatory demyelinating polyneuropathy or inherent immune deficits.

Furthermore, the increasing occurrence of immunological and neurological diseases and growing off-label indications for IVIg, since it offers relief to patients with systemic lupus erythematosus and advances the cardiac consequences in babies borne by females with antiphospholipid syndrome throughout pregnancy, are powering the sales of the products.

The neurology category dominated the industry, of about 28%, in 2022, because of the extensive usage of plasma-derived products for treating neurological ailments, which are increasing in incidence.

The oncology category will grow the fastest in the future, because the acceptance of cancer plasma treatments is rapidly increasing for addressing hard targets that were previously intractable, for example those with the probability for metastasis and resistance to drugs.

Moreover, a detailed examination of the intricate effects of cold atmospheric plasma in the treatment of cancer is essential to move on the road to its extensive clinical acceptance, which supports the expansion of the category.

North America led the share of plasma fractionation market, of about 55%, in 2022. This is because of the continuing expansion in the pharma research and development sector, increasing populace of patients suffering from hemophilia, increasing count of plasma collection centers, increasing paid plasma donation actions, and increasing portfolios of the products and presence of key players in the region.

It is because of the increasing elderly population all over the world, the requirement for plasma fractionation is on the rise in the years to come.

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Professional Hygiene Industry Growth, Development and Future Analysis

Professional Hygiene Market

The professional hygiene market generated a value of USD 16,089 million in 2022, and it will touch USD 23,953 million, propelling at a 5.10% compound annual growth rate, by 2030.

The progress of the industry is mainly ascribed to the increasing health concerns due to the infections caused as a result of microbial growth within commercial places. Furthermore, because of the rising staff at workplaces, the usage of restrooms by more individuals within the same amount of time increases the infection risk. In addition, due to the growing requirement for hygiene and cleanliness at hotels, the industry is growing.

In 2022, the hospitality category, based on application, accounted for the largest industry share, of approximately 40%. This is attributed to the increasing need for hygiene maintenance products in the hospitality sector, as a result of the increasing population, growing tourism activities, and individuals shifting from rural to urban areas.

Furthermore, since the COVID-19 pandemic, there has been a massive rise in people’s attention on health and hygiene. Because of this, the hospitality sector has advanced its hygiene standards, by offering tissues & sanitizers and frequently disinfecting the areas.

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Based on distribution channel, the offline category accounted for largest professional hygiene market share, of 84% in 2022. This is because of the accessibility of a numerous products of different brands with big discounts and offers at hypermarkets and supermarkets.

In 2022, the tissues and napkins category, based on product, largest industry share, of over 81%. This is ascribed to the rising consciousness of hand hygiene in workplaces and increasing incidence of healthcare-associated infections (HAIs). Moreover, tissue and napkins are the most-commonly utilized products for hand drying at hotels, offices, and hospitals.

Moreover, the technological advancement in tissues manufacturing, increasing disposable incomes, initiatives of government to support public health, and advent of organic tissue paper and enhanced ways of dispensing are boosting the growth of the industry.

In 2022, North America accounted for the largest professional hygiene industry share, of over 32%. This is because of the growing international tourism activities, growing health awareness, and increasing hospitality sector. Moreover, the increasing international arrivals in Canada and the U.S. are led by the various trade fairs, international events, sports events, and film festivals held in this region, along with their cultural and natural charm.

Moreover, the increasing incidence of healthcare-associated infections resulted in the increasing need for sanitizers, soaps, and other wiping and cleaning products in the healthcare sector.

It is because of the growing people consciousness regarding infection control, as well as increasing requirement for hygienic work environment, the professional hygiene industry will continue to advance in the years to come.