novembre 2023 - World Wide Trends

30 novembre 2023

High Prominence of Downstream Processing Due to Reduced Operational Cost

Downstream processing can be defined as the series of operations for biological materials such as plant tissues, tissue culture fluid, and cells to derive them from a homogenous product. The rising expenditure on research & development in the biopharmaceutical sector, along with the growing prevalence of contract manufacturing organizations, and the expansion of the biotechnology sector leads to increasing adoption of downstream processing.

In 2021, the downstream processing industry generates $21.1 billion, and it is expected to capture $51.0 billion in 2030, advancing at a rate of 10.3% from 2021 to 2030. The product is initially enclosed in the biological matrix with a massive number of varying non-target molecules. Moreover, downstream processing involves multiple processes that incrementally boost the target’s purity by exploiting its chemical and physical properties, making it distinct from contaminants.

Downstream processing involves harvesting and clarification steps for separating bulk contaminants from it such as carbohydrates, particulates, and oils, after polishing and capturing, and refining the feed stream till only the target product is left.

Moreover, downstream processing for energy effectiveness constitutes multistage unit operations after upstream processes that help in the enhancement of the final product’s quality in terms of both purity and concentration.

The major objective of downstream processing, along with maximizing the recovery rate of the product, is to minimize the production cost. The cost-effective production largely relies on the product’s nature, selection of feedstocks, as well as fermentation process, along with immobilized cells fermentation, free cells, and catalyst types.

In addition, downstream processing is an integral part of the entire production process, and numerous factors affect it. Along with bioprocess, raw materials usage, and specifications of the final product relies on DSP. It includes formulation, or direct in situ use, such as polymerization. Around 50% to 90% of the total production cost is consumed by the DSP.

The selection of the DSP relies on the type of microorganism, fermentation process, product substrate, along with target application. Varying combinations of steps with varying unit operations are utilized in most cases. As it is mentioned, numerous by-products could be generated from succinic acid fermentation, possessing similar structures and properties, such as lactic acid, and malic acid, along with their selective separation that largely affects DSP costs.

Downstream processing constitutes all unit operations after fermentation to enhance the final product, ethanol’s purity. Usually, combinations of molecular sieving and distillation are used for ethanol purification.

Ethanol contains only 5% of moisture, that is dehydrated while using azeotropic distillation. The water presence improves ethanol’s molecular polarity and keeps it separate when mixed with gasoline. Entrainer, a third chemical is then added, in azeotropic distillation. In large-scale ethanol purification, molecular sieving methods are implemented, as azeotropic distillation is expensive.

In the pharmaceutical sector, downstream processing holds a greater prominence in significantly reducing the whole manufacturing process cost. Microfiltration, ultrafiltration, nanofiltration, and reverse osmosis are largely utilized for pharmaceuticals’ downstream processing due to ease of operations.

Therefore, downstream processing is essential and holds a greater prominence in the biopharmaceutical, and biotechnology sectors in significantly reducing the operational cost.

28 novembre 2023

Clinical Trials Outsourcing Industry to Observe Fastest Growth In Asia-Pacific

The clinical trials outsourcing market will touch USD 75,573.4 million, advancing at a 7.2% compound annual growth rate, by 2030.

The advancement in this industry can be ascribed to the surging requirement to enhance efficiency and lessen research and development expenses. Furthermore, the growing count of non-communicable and communicable diseases, mounting research & development activities to manufacture new medicines, and the rising pharmaceutical & biopharmaceutical sectors, are also boosting the progression of this industry.

Additionally, governments in some nations are increasing their focus on the healthcare sector, because of the mounting incidence of people with chronic illnesses, for instance, cardiovascular diseases, lung cancer, and diabetes. Moreover, non-government and government organizations are also rising their focus on the efficacy and safety of the drug.

The phase-3 category, based on phase, held the largest share of the industry, of over 36%, in the past few years. This is because of the large number of clinical trials present in the stage of phase-3 and the high failure possibility in clearing this stage, which encourage pharmaceutical businesses to partner with outsourcing partners.

The small & mid-sized companies category, based on end user, is expected to dominate the clinical trials outsourcing market in the years to come. This is because of the increasing number of contract research organizations, mainly in Asian nations such as China, Japan, and India, which provide solutions for end-to-end clinical trials, enabling resource flexibility, resource sharing, operational capabilities expansion, and cost-efficiency.

In the past few years, the cancer category, based on application, accounted for the largest share in the industry. This is primarily because of the surging incidence of cancer, which needs precise medications to prevent, reduce pain, and cure cancer.

The nervous system disorder category will observe the highest growth rate in the years to come. This is because of the surging incidence of nervous system disorders, such as migraine, tension-type headaches, traumatic brain injury, and dementias. Furthermore, the unavailability of important medications is boosting the requirement for drug development.

The North American industry accounted for the largest share in recent years. This is because of the existence of enhanced healthcare infrastructure, an increasing number of innovative drug research studies, high healthcare spending, the existence of major players, and high funding for clinical trials in the continent.

APAC will observe the fastest growth in the industry, with more than 7.5% CAGR, in the years to come. This is primarily because of the rising activities of drug research, the increasing incidence of diseases, and the advancing healthcare infrastructure in the continent.

It is because of the increasing production of new medications and the growing number of contract research organizations, the clinical trials outsourcing industry will continue to advance in the years to come.

28 novembre 2023

Biologics CDMO Secondary Packaging Industry Will Grow Fastest in Asia-Pacific

The biologics CDMO secondary packaging market will touch USD 3,622.6 million by 2030, powering at a rate of 8.7% by the end of this decade. This growth is credited to the snowballing drug production, the increasing pharma industry, and the growing prevalence of numerous diseases, such as chronic ailments, infectious ailments, and genetic diseases.

Boxes were the largest category in the industry, with about USD 1 billion revenue, in 2021, and they will continue dominations in the years as well.

Boxes are designed explicitly for the transport of biological products, such as frozen and controlled ambient biologics. They also provide the perfect balance between temperature control and payloads.

North America had the largest revenue share, more than 40%, in the biologics CDMO secondary packaging market. This is because of the increasing outsourcing of drug research and development and production activities by major biopharma players.

Numerous companies wish to team up with competent packing providers providing non-conventional packing solutions and have the vital capabilities to formulate exclusive packing designs in a time and cost-effective manner.

Instead, the APAC will have the fastest growth in the years to come. This growth has a lot to do with the increasing prevalence of chronic ailments, the growing emphasis of businesses on contract manufacturing, and key players are keenly interested in facility developments in the Asia Pacific region.

Furthermore, the growth of the European region will be moderate in nature in the years to come. This can be mainly as a result of the increasing requirement for biologic products, for instance vaccines, driving the research and development spending of the pharma companies.

Due to the increased production of drugs all over the world, the demand for biologics CDMO secondary packaging is on the rise, and this trend will continue in the years to come as well.

28 novembre 2023

Hematology Testing – Industry Growth and Future Analysis

The hematology testing market generated a value of USD 3,987.4 million in 2022, and it will touch USD 6,335.9 million, growing at a 6.0% compound annual growth rate, by 2030.

The growth of the industry is mainly because of the increasing incidence of blood-related illnesses and the growing usage of high throughput hematology analyzers as well as advancements in technology.

In 2022, the consumables category, based on product, contributed a larger revenue share, of approximately 70%, and it will also observe a higher growth rate, of approximately 7%, in the years to come. The growth in this category is primarily because of the widespread adoption of numerous reagents and test kits to perform hematology testing.

In 2022, the reagents category, among the consumables, accounted for the largest share of approximately 60%, and it will exhibit the highest growth rate of approximately 5% in the years to come. This is because of the mounting number of laboratory tests number, as a result of the growing prevalence of infectious and chronic illnesses.

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In 2022, the global hematology diagnostics industry is led by North America, with approximately USD 2 billion, owing to the advantageous patient demographic, favorable policies of reimbursement, and increasing incidence of numerous types of blood diseases in the region.

APAC will observe the highest growth rate in the industry, of approximately 8%, in the years to come, owing to the mounting number of blood camps, growing government investments, rising consciousness about blood donation, and increasing blood disorders incidence in the region.

Moreover, India and China together hold over 50% share of the APAC industry, owing to the high acceptance of flow cytometry in these nations.

Hence, with the increasing incidence of blood-related illnesses and mounting acceptance of high-throughput hematology analyzers, the hematology testing industry will continue to advance in the years to come.

24 novembre 2023

Here are 7 Superfoods for Optimal Skin Health

When it comes to achieving glowing and radiant skin, people often rely on expensive skincare products and beauty treatments. However, what many people tend to overlook is the significant impact of their diet on skin health.

The saying “you are what you eat” holds for our skin as well. Consuming a balanced diet that includes skin health foods can work wonders for maintaining a clear, youthful, and vibrant complexion.

Let’s explore seven superfoods that can contribute to optimal skin health, providing essential nutrients and promoting a natural, healthy glow.

Avocado

Known for its high content of healthy fats, avocados are a powerhouse of skin-friendly nutrients. They are packed with monounsaturated fats that help keep the skin moisturized and flexible, reducing the appearance of fine lines and wrinkles.

Additionally, avocados contain vitamins E and C, which act as potent antioxidants, protecting the skin from oxidative damage caused by free radicals.

Sweet Potatoes

Rich in beta-carotene, sweet potatoes are a skin-friendly food that can give your skin a healthy glow. Beta-carotene is converted to vitamin A in the body, which is essential for skin cell turnover and repair. Regular consumption of sweet potatoes can help prevent dry, flaky skin and promote a smoother texture.

Green Tea

Green tea is not only a soothing beverage but also a potent skin health booster. It contains catechins, which have anti-inflammatory and antioxidant properties that can help reduce redness and inflammation. Additionally, green tea can help protect the skin from damage caused by sun exposure and pollution.

Greek Yogurt

Greek yogurt is a great source of probiotics, which play a vital role in promoting a healthy gut. A balanced gut microbiome can positively impact skin health by reducing inflammation and preventing skin conditions like acne and eczema.

Dark Chocolate

Indulging in moderate amounts of dark chocolate (with high cocoa content) can be beneficial for your skin. Dark chocolate is rich in flavonoids, which can enhance blood flow to the skin, improve hydration, and protect against sun damage. Additionally, the antioxidants in dark chocolate can help combat free radicals, promoting a more youthful appearance.

Nuts and Seeds

Almonds, walnuts, chia seeds, and flaxseeds are excellent sources of healthy fats, antioxidants, and vitamins that benefit the skin. Vitamin E in nuts and seeds helps protect the skin from UV damage, while their omega-3 fatty acids maintain skin elasticity and hydration.

Salmon

Salmon is an excellent source of omega-3 fatty acids, which are essential for maintaining skin health. These healthy fats help to keep the skin hydrated and reduce inflammation, promoting a clear and radiant complexion. Omega-3s also support the skin’s natural barrier, which protects against environmental pollutants and irritants.

Additionally, the consumption of fatty fish and walnuts is very high due to the high presence of fatty acids, these acids have numerous benefits, which is why they are now being increasingly utilized in the skincare and beauty industry.

Moreover, these skin health foods are consumed by both adults and elderly people, however, because of the larger population of adults than that of elderly people around the world, these foods are mostly consumed by adults.

Incorporating these skin-boosting foods into your diet, along with a good skincare routine, proper hydration, and sufficient sleep, can contribute to achieving radiant, beautiful skin that glows from within.

Moreover, with the surging R&D spending by a large number of local and foreign businesses producing functional foods and the rising knowledge of the health benefits of functional foods across Asian countries, the need for skin health foods is increasing, and it will reach a value of USD 3,438.9 million by the end of this decade.

22 novembre 2023

Metagenomic Sequencing Industry Share, Growth and Future Analysis

The metagenomic sequencing market was USD 1,938 million in 2022, and it will reach USD 6,899 million, advancing at a 17.20% compound annual growth rate, by 2030.

The growth in the industry is because of the decreasing cost of this technique. Furthermore, the implementation of this technique is increasing in agricultural biotechnology, where it allows the analysis of the whole genome in an environmental sample without the need for culturing.

In 2022, the drug discovery category, based on application, held the largest share, of over 26%, and it will remain the largest in the years to come. This is because of the rising activities of research in the biotechnical and pharmaceutical industries for novel drug discovery, regularly as part of partnerships between academic institutes and industry players.

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Whereas, the clinical diagnostics category will observe the highest growth rate in the metagenomic sequencing market, in the years to come. This is primarily because of the increasing prevalence of infectious illnesses and the production of tools and software for genomic research.

The shotgun metagenomic sequencing category, based on technology, held the largest share, and it will remain the largest in the years to come. This is because of the surging genomic-based research activities led by academic and research institutes and the benefits provided by this technique as compared to other techniques.

In 2022, the sequencing category, based on workflow, accounted for the largest share of the metagenomic sequencing industry, and it will remain the largest in the years to come.

Sequencing methods are regularly utilized by research scientists and healthcare institutions for genetic studies, which is an important component of genetic testing. The price of sequence modeling has dropped by approximately 28% annually because of technological advancements, which would boost its utilization.

In 2022, North America accounted for the largest share, of over 42%, and it will observe a strong growth rate in the years to come. This is because of the higher risk of illnesses, extensive R&D activities in the pharmaceutical and biotechnology sectors, ad full-bodied support for the setup of new R&D facilities, and the presence of reputable healthcare businesses in the continent.

Whereas, APAC will observe the fastest growth rate in the years to come. This is because of the surging investment by domestic and international businesses, government support for research in advanced healthcare areas, development of the healthcare infrastructure, and a large pool of patients with infectious and chronic illnesses.

With the increasing incidence of genetic and infectious illnesses, as well as government investments in healthcare research and development, the metagenomic sequencing industry will continue to grow in the years to come.

21 novembre 2023

Plasma Fractionation Industry Development and Forecast Report 2030

The plasma fractionation market will observe a rate of 7.4% by the end of this decade, to reach USD 50,638 million by 2030.

The industry growth has a lot to do with the fast increase in the elderly population, susceptible to various rare disorders creating the requirement for plasma derivatives for treatment.

Furthermore, the industry is expanding because of the growing use of immunoglobulins in numerous therapeutic areas, increasing incidence of breathing problems, and mounting network of facilities of plasma collection.

The surge in the geriatric population all over the world is also a key factor accountable for the growing incidence of numerous uncommon disorders that require the usage of blood derivatives. With the count of people aged 65 and above will cross 1.5 billion by 2050, the use of the plasma fractionation method for deriving Ig and other therapeutic agents from the blood will increase.

On the basis of the product type, the immunoglobulins category will grow significantly at a rate of 7.9%, in the years to come. This is because of the wider commercial obtainability of plasma-derived immunoglobulins as opposed to other products and their growing use, particularly for treating patients with chronic inflammatory demyelinating polyneuropathy or inherent immune deficits.

Furthermore, the increasing occurrence of immunological and neurological diseases and growing off-label indications for IVIg, since it offers relief to patients with systemic lupus erythematosus and advances the cardiac consequences in babies borne by females with antiphospholipid syndrome throughout pregnancy, are powering the sales of the products.

The neurology category dominated the industry, of about 28%, in 2022, because of the extensive usage of plasma-derived products for treating neurological ailments, which are increasing in incidence.

The oncology category will grow the fastest in the future, because the acceptance of cancer plasma treatments is rapidly increasing for addressing hard targets that were previously intractable, for example those with the probability for metastasis and resistance to drugs.

Moreover, a detailed examination of the intricate effects of cold atmospheric plasma in the treatment of cancer is essential to move on the road to its extensive clinical acceptance, which supports the expansion of the category.

North America led the share of plasma fractionation market, of about 55%, in 2022. This is because of the continuing expansion in the pharma research and development sector, increasing populace of patients suffering from hemophilia, increasing count of plasma collection centers, increasing paid plasma donation actions, and increasing portfolios of the products and presence of key players in the region.

It is because of the increasing elderly population all over the world, the requirement for plasma fractionation is on the rise in the years to come.

21 novembre 2023

Professional Hygiene Industry Growth, Development and Future Analysis

The professional hygiene market generated a value of USD 16,089 million in 2022, and it will touch USD 23,953 million, propelling at a 5.10% compound annual growth rate, by 2030.

The progress of the industry is mainly ascribed to the increasing health concerns due to the infections caused as a result of microbial growth within commercial places. Furthermore, because of the rising staff at workplaces, the usage of restrooms by more individuals within the same amount of time increases the infection risk. In addition, due to the growing requirement for hygiene and cleanliness at hotels, the industry is growing.

In 2022, the hospitality category, based on application, accounted for the largest industry share, of approximately 40%. This is attributed to the increasing need for hygiene maintenance products in the hospitality sector, as a result of the increasing population, growing tourism activities, and individuals shifting from rural to urban areas.

Furthermore, since the COVID-19 pandemic, there has been a massive rise in people’s attention on health and hygiene. Because of this, the hospitality sector has advanced its hygiene standards, by offering tissues & sanitizers and frequently disinfecting the areas.

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Based on distribution channel, the offline category accounted for largest professional hygiene market share, of 84% in 2022. This is because of the accessibility of a numerous products of different brands with big discounts and offers at hypermarkets and supermarkets.

In 2022, the tissues and napkins category, based on product, largest industry share, of over 81%. This is ascribed to the rising consciousness of hand hygiene in workplaces and increasing incidence of healthcare-associated infections (HAIs). Moreover, tissue and napkins are the most-commonly utilized products for hand drying at hotels, offices, and hospitals.

Moreover, the technological advancement in tissues manufacturing, increasing disposable incomes, initiatives of government to support public health, and advent of organic tissue paper and enhanced ways of dispensing are boosting the growth of the industry.

In 2022, North America accounted for the largest professional hygiene industry share, of over 32%. This is because of the growing international tourism activities, growing health awareness, and increasing hospitality sector. Moreover, the increasing international arrivals in Canada and the U.S. are led by the various trade fairs, international events, sports events, and film festivals held in this region, along with their cultural and natural charm.

Moreover, the increasing incidence of healthcare-associated infections resulted in the increasing need for sanitizers, soaps, and other wiping and cleaning products in the healthcare sector.

It is because of the growing people consciousness regarding infection control, as well as increasing requirement for hygienic work environment, the professional hygiene industry will continue to advance in the years to come.

20 novembre 2023

Multiparameter Patient Monitoring Systems Industry Growth and Forecast Report 2030

The multiparameter patient monitoring systems market generated a value of USD 9,789.2 million in 2022, and it will touch USD 17,950.8 million, advancing at a 7.9% compound annual growth rate, by 2030.

The growth of the industry can be because of the rising incidence of chronic sicknesses, the growing count of surgical processes, and the mounting need for early illness diagnosis.

Moreover, hospitals are growingly concentrating on monitoring the conditions of patients at each treatment stage, which has resulted in the increasing implementation of real-time monitoring systems for patients to help in making suitable clinical decisions.

In 2022, the hospitals category, based on end user, accounted for the dominating share in the industry, of approximately 70%. This can be attributed to the fact that an enormous count of patients with chronic illnesses, injuries, or any other medical emergencies visited hospitals each day.

North America accounted for the dominating share in the industry. This can be because of the existence of a strong healthcare system, advancement in technologies, high expenditure on healthcare facilities, high occurrence of illnesses, growing count of surgical processes, and rising consciousness of the people concerning effective management of disease.

APAC will advance at the highest rate in the years to come. This is because of the high progression in the economy, rising consciousness of constant health monitoring, unfulfilled medical requirements of the vast populace, and the growing per capita income.

It is because of the surging occurrence of chronic illnesses, the mounting number of surgeries, and the increasing need for early disease diagnosis, the multiparameter patient monitoring systems industry will continue to advance in the years to come.

17 novembre 2023

Rising Occurrence of CVDs and Obesity Boosts PTA Balloon Catheter Market

The PTA balloon catheter market was USD 2,231.6 million in 2022, which is likely to touch USD 4,591.2 million, propelling at a 9.4% compound annual growth rate, by 2030.

The growth of this industry is mainly because of the rising occurrence of obesity and CVDs, increasing tobacco consumption, and the surging count of minimally invasive surgical processes.

In 2022, the nylon category, based on material type, was the largest contributor to the industry. This is primarily because nylon catheters are scratch-resistant and have greater patient compliance.

North America was the largest contributor to the industry in 2022, with approximately 35% share. For many years, CVDs have been a key cause of mortality in the U.S. According to the CDC, in 2021, 0.69 million individuals in the U.S. died of heart ailments, with over one demise each minute.

APAC is advancing at the fastest rate, primarily due to the surging occurrence of problems associated with the heart as well as the mounting elderly populace. Moreover, the most common heart ailments in India are coronary artery disease, cardiomyopathy, rheumatic heart disease, cerebrovascular disease, valvular heart disease, heart failure, and heart attack.

Furthermore, factors like economic advancement as well as the increasing healthcare spending will further boost the growth of the regional industry.

With the mounting incidence of CVDs and obesity coupled with increasing tobacco usage, the PTA balloon catheter industry will continue to progress in the years to come.